HPMC Controlled GRADE RELEASE

Back to all Products
Contact Us

75HD-CR is a dedicated HPMC which is designed specialize for hydrophilic gel matrix material, high viscosity grade also available.

Advantages for the hydrophilic gel skeleton drug release system:
1. Simple Prescription design
2. Completely dissolved of tablet, high bio availability
3. Choosing appropriate 75HD-CR grade, can be easily control the release curve
4. Hydrophilic gel matrix tablet is a kind of economic sustained-release products, use 75HDCR product prepared hydrophilic gel matrix tablets when met with water will form a gellayer, which is the basis for control drug release. Different 75HD-CR grade will influence the initial wetting.

Expansion, hydration and gel strength. In the initial swelling stage, hydroxypropyl methyl cellulose particles on the surface of the tablet begin to partially hydrated , and the gel layer has not yet been fully formed, thus in this stage erosion or dissolution can been seen on the surface of the tablet sometimes.

Sustained release tablets use75HDCR products as hydrophilic gel matrix materials, drug release is affected by many factors

Influencing Factors
Advantages
Solubility of the drug
The main parameters are the pKa values of the drug and their solubility in different pH release media
HPMC Characteristics
Degree of Substitution
Viscosity
Particle size distribution
Particle morphology
Prescription factors of drug agent
Content of HPMC
Nature of other excipients
Process factors of drug agent
Whether use power direct pressure process or wet granulation tablet process, tableting pressure, size and shape, coating or not

Applications

Specification
75HD100CR
75HD4000CR
75HD15000CR
75HD100000CR
Reference usage
5-75%
Advantages
Sustained release matrix tablets; has the fastest rate of hydration 75HDCR specification
Applications
Control
released agent